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 WHO Assesses H1N1 Virus Mutation In Norway 
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Post WHO Assesses H1N1 Virus Mutation In Norway
WHO Assesses H1N1 Virus Mutation In Norway

2009, November 21 - VisitBulgaria.com

"According to the UN agency, apart from Norway, countries like Brazil, China, Japan, Mexico, Ukraine and the United States also detected the mutation sometime in early April."

http://visitbulgaria.info/11885-who-ass ... z0XWAZDwM2


Mutated pig influenza viruses in Norway and the UK

Doctors newspaper online, 21.11.2009 -Translated from German - excerpt

OSLO / LONDON / GENEVA (AP). "In Norway and Britain have different mutated swine influenza viruses detected. In both cases, the doctors are moving on but not from a higher risk potential. The vaccines are effective against the mutated virus. In Britain, people first infected with another variant of swine flu, does not act against the drug Tamiflu ®.

The five British patients at a hospital in Wales is based on findings from public health authorities around the world's first cases of transmission of such resistant virus from person to person. At least three of the patients had been infected directly from the station of the University Hospital in Cardiff, where they had been treated for other serious diseases."

http://tinyurl.com/yk5ucog


"The swine flu mutation found in Norway resulted in severe respiratory distress. The Norwegian Institute of Public Health stated that the mutation gave the virus a greater ability to affect the respiratory system, allowing it to cause more damage. Ukraine flu symptoms reportedly include bleeding in the lungs."

http://tinyurl.com/yz2pzhr

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Sat Nov 21, 2009 12:46 pm
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Post Re: WHO Assesses H1N1 Virus Mutation In Norway
Scientists announce H1N1 mutation
By DELANIA TRIGG, Register Staff Writer

Just when you thought you’d heard enough about H1N1, comes the unwelcome news that the virus is changing.

Norwegian health authorities said Friday they have discovered a potentially significant mutation in the H1N1 influenza strain.

The change may allow the virus to penetrate deeper into the respiratory tracts of certain individuals causing more severe symptons and in some cases, death, an official with the World Health Organization (WHO) said recently.

H1N1 is responsible for at least 6,770 worldwide deaths since the virus emerged in April, according to the latest WHO update which showed 520 known fatalities in the past week.

News of the mutation is the latest in a seemingly relentless barrage of media coverage about the virus.

snip

What troubles research scientists is the tendency of viruses to change, he said.

While H1N1 does not appear to be a particularly deadly virus, Fletcher said it pays to be vigilant.

“The situation definitely bears watching,” he said.

http://www.ktre.com/Global/story.asp?S=11550606

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Mon Nov 23, 2009 12:00 pm
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Post Re: WHO Assesses H1N1 Virus Mutation In Norway
Quote:
WHO investigating Norway swine flu mutations

http://www.google.com/hostednews/ap/art ... D9C3EQKG0#


(AP) – 3 days ago

GENEVA — The World Health Organization said Friday it is investigating samples of variant swine flu linked to two deaths and one severe case in Norway, but that so far the significance of the mutation is unclear.

Norway's Institute of Public Health announced Friday that the mutation "could possibly...cause more severe disease" because it infects tissue deeper in the airway than usual.

The mutation was found in three of 70 analyzed swine flu cases, said Geir Stene-Larsen, the institute's director.

Stene-Larsen said he does not believe the mutant virus is circulating in the general population in Norway, where about 680,000 people are estimated to have been infected with swine flu to date and 23 have died.

The same mutation has been found in both fatal and mild cases elsewhere, including in Brazil, China, Japan, Mexico, Ukraine, and the United States, said WHO.

In addition, "worldwide, viruses from numerous fatal cases have not shown the mutation," the global body said. "The public health significance of this finding is thus unclear."

"Just to say that the mutated virus infects deeper tissue doesn't really tell us very much," WHO spokesman Thomas Abraham told The Associated Press. "What we really need is more clinical and epidemiological data."

WHO said the anti-viral drugs still appear to be effective against viruses with the mutation, and studies show that currently available pandemic vaccines confer protection against the variant strain.

Virus mutations occur spontaneously and many have no effect on the danger a virus poses to humans.

"Although further investigation is under way, no evidence currently suggests that these mutations are leading to an unusual increase in the number of H1N1 infections or a greater number of severe or fatal cases," said WHO.

Meanwhile the Geneva-based agency updated its global tally of deaths caused by the virus to over 6,750.

It said transmissions appear to have peaked in some parts of the United States and Western Europe, but elsewhere the number of cases is still increasing, including in eastern Europe, and Central and Western Asia.

Copyright © 2009 The Associated Press.


Mon Nov 23, 2009 5:16 pm
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Post Re: WHO Assesses H1N1 Virus Mutation In Norway
H1N1 Mutation Found In Hong Kong




# 4070





In an announcement today Hong Kong authorities tell of a year-old boy hospitalized for 3 days last July who tested positive for the same mutation in the H1N1 virus as made headlines last week.



The amino acid change in the HA1 gene at position 222 (225 in influenza H3 numbering) from aspartic acid (D) to glycine (G) had been found in three cases of severe pandemic Influenza in Norway.



The assumption by some has been that this mutation must increase the virulence of the virus because it was found in several severe cases in Norway, some with fatal outcomes.



While it may indeed prove to be a factor in the virulence of H1N1, what we don’t have a good handle on is how many mild cases have occurred with this mutation?



Without knowing that, it is very difficult to assess the relative dangers of this single amino acid substitution.




The case announced today would appear only to have been of moderate severity, as the child was only hospitalized for 3 days and has fully recovered.



The other key point here is that of 123 samples tested in Hong Kong, only one showed the mutation.



Which would suggest it isn’t widespread in that community, and may simply be a spontaneous mutation.



Also, the boy’s family did not fall ill, and the virus remained sensitive to antivirals.



The significance of this mutation is not yet clear. But each day brings us more data which will hopefully give us a better idea in the weeks and months to come.



Two reports:



Quote:
H1N1 flu virus mutation detected in HK

www.chinaview.cn 2009-11-24 07:33:52

HONG KONG, Nov. 23 (Xinhua) -- Hong Kong's Department of Health announced Monday that it had found the same mutation in a H1N1 flu virus sample as the one detected in Norway recently.



The department said that it had examined the genetic sequence of H1N1 flu viruses in its monitoring system. Out of the 123 sequences studied, one sample showed the same mutation as the Norway strain.



The virus was taken from a year-old boy who developed flu-like symptoms July 22. He was admitted to Prince of Wales Hospital July25 and discharged three days later. He has recovered.



Mutations are frequently encountered in influenza viruses. According to the World Health Organization, the same mutation of the virus has been found on the Chinese mainland and in other countries, including Brazil, Japan, Mexico, Ukraine and the United States.



The virus with this mutation remained sensitive to antiviral drugs, Tamiflu and Relenza. No evidence suggests these mutations are leading to an unusual increase in the number of H1N1 flu infections or a greater number of severe or fatal cases.



And an excerpt from the Hong Kong Standard





Quote:
Mutated swine flu found in tot
Mary Ann Benitez
Tuesday, November 24, 2009

EXCERPT

The Department of Health announced last night that it found the same mutation in the boy, who developed symptoms on July 22 and tested positive for the virus on July 25 when he was admitted to Prince of Wales Hospital.



He was discharged on July 28 and recovered completely. His family members did not fall ill.



A department spokesman said: "The virus with this mutation remained sensitive to antiviral drugs oseltamivir [Tamiflu] and zanamivir [Relenza]."



The spokesman said there is no evidence that these mutations are leading to an unusual increase in the number of swine flu infections or a greater number of severe or fatal cases.

<SNIP>



Stene-Larsen added: "Based on what we know so far, it seems that the mutated virus does not circulate in the population, but might be a result of spontaneous changes."


http://afludiary.blogspot.com/2009/11/h ... -kong.html

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Mon Nov 23, 2009 8:40 pm
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Post Re: WHO Assesses H1N1 Virus Mutation In Norway
ECDC On Norway Mutation & Tamiflu Resistance





# 4065



The ECDC (European Centre for Disease Prevention and Control) releases a daily (5 times a week) update on the influenza pandemic, with the latest numbers along with update on recent news and their analysis or comments.



On Friday of last week 3 big stories carried the day; the announcement by the Norwegian Health Officials that they’d discovered a mutation in the H1N1 virus and two separate reports (North Carolina & Wales) of multiple cases of Tamiflu resistance.



Not surprisingly, wild Internet rumors, rampant speculation, and conspiracy theories have already begun to appear regarding these events. What most of these stories lack in logic and evidence they make up for with imagination and chutzpah.



Before I get letters, I will gladly stipulate that `official statements’ from many government agencies (and NGOs) from around the world are often carefully crafted to impart a reassuring tone, sometimes gloss over important information, and must be read with a certain amount of skepticism as well.



Some official sources are more reliable than others, but Caveat Lector is a good policy, regardless of the source.





Today the ECDC releases their Monday morning update with some analysis of the events of late last week. This is a far more detailed release of information than we saw from the WHO on Friday.


Quote:
Mutation in the Haemagglutinin gene of pandemic Influenza A(H1N1)v reported from Norway

The Norwegian Institute of Public Health reported on 20 November 2009 the detection of a mutation in the viruses affecting three cases of severe pandemic Influenza A(H1N1)v infection.



Overall approximately 70 influenza viruses from ill patients have been sequenced in Norway, including six from patients who died. The three viruses with this mutation were isolated from the first two fatal cases of pandemic influenza in Norway and one patient with severe respiratory disease.



The two fatal cases , who were not epidemiologically linked, died in July and August, 2009. Based on the currently available information it appears that the mutated virus is not circulating in the Norwegian population, but may the result of a spontaneous change occurring in severely ill patients [1].



In a note responding to the report from Norway WHO reported that worldwide, a similar mutation has been was detected in viruses from several other countries, with the earliest detection reported in April. In addition to Norway, the mutation has been observed in Brazil, China, Japan, Mexico, Ukraine and the USA.[2]

Link1

Link2



ECDC comment:


Quote:
The amino acid change in the haemagglutinin HA1 gene at position 222 (225 in influenza H3 numbering) from aspartic acid (D) to glycine (G) observed, may influence receptor binding specificity and therefore has the potential to affect the pathogenicity of the virus.



This might allow the mutated virus to infect tissues deeper in the respiratory tract, although the receptor binding preferences have not been determined yet. Currently, there is no evidence about the consequences of this mutation on the biological properties of the virus.



In addition, if the receptor preference of the mutated virus corresponds to the deeper airways, this most likely will tend to reduce the likelihood for easy human-to-human spread. A likely explanation of this finding is that it is an adaptive mutation of the virus.



At this moment there is no indication of change in the virulence of the circulating pandemic Influenza A(H1N1)v virus. The virus with this mutation remains sensitive to oseltamivir and zanamivir. Studies show that the currently available vaccines confer protection.



Continued close virological monitoring in particular of severe cases, is needed to elucidate any potential relationship between the mutation and the clinical outcome of infection.


con.

http://afludiary.blogspot.com/2009/11/e ... miflu.html

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Mon Nov 23, 2009 8:54 pm
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